Calmex Capsules

Product Information

Araujo et al. 2010. Anxitane tablets reduce fear of human beings in a model of anxiety-related behaviour. Journal of Veterinary Behavior 5, 268-275

Dietary Management – Not suitable for acute development of anxiety and the anxiolytic effects are limited. Much more beneficial to use a tryptophan supplement. Ernst, E. 2007, “A re-evaluation of kava (Piper methysticum)”, British journal of clinical pharmacology, vol. 64, no. 4, pp. 415-417.

Anxiolytics such as benzodiazepines are used to provide short term relief from anxiety. Benzodiazepines such as diazepam provide short term CNS sedation. For treatment of serve anxiety and phobias, long term use of benzodiazepines may be prescribed by a veterinarian; however, this can lead to dependence and the development of withdrawal symptoms likened to Lyrica withdrawal symptoms in the past.

Pheromones – Controversy still surrounds their actual efficacy, DAP does show some promise however its use requires prior preparation meaning it is not suitable for acute development of anxiety such as that experienced with sudden fireworks. L-Tryptophan 120mg, Rhodiola rosea 50mg, Lecithin 45mg, Passiflora incarnata 40mg, Niacinamide 3mg, Vitamin B1 0.3mg, Vitamin B6 0.3mg In Cats: Inappropriate elimination, Vertical scratching, Aggression, Over-grooming, Self-mutilation, Hiding or withdrawn behaviour, Clingy or needy behavior, Changes in appetite, A state of hypervigilance.

Equine Sachets

Daily routine will also be likely to alter; these factors combined with an absence of the owner can be distressing for the dog. Treating the dog pre-emptively for anxiety would obviously be beneficial. An amino acid precursor to serotonin.Regulation of serotonin can improveanxiety and stress as it has a rolein many physiological functions.Supplementation in dogs has beenfound to reduce anxiety signs. Because the active ingredients of CALMEX ® work rapidly, it can be used for acute situations without requiring prior preparation, perfect for unexpected situations. Conclusion Pharmaceuticals – Can have good anxiolytic effects (and in some cases amnesic). The optimal pharmaceutical for anxiety treatment would be benzodiazepines however; it can produce a number of side effects including paradoxical hyperactivity.

There are a number of side effects associated with these drugs including; unwanted sedation, constipation, diarrhoea, urinary retention, appetite changes, ataxia, cardiac arrhythmia and alterations in blood pressure. The Polynesian herb kava kava (Piper methysticum) is a musculoskeletal relaxant that helps people and dogs cope with stress and distractions. ADAPTIL CalmOn-The-GoCollaris an excellent solution to help your dog stay calm and adapt even outdoors. The active ingredient of Zylkéne is alpha-casozepine, a decapeptide which is isolated from bovine tryptic-casein. It is worth noting that Zylkéne relies solely on this single active ingredient. Calmex is a calming supplement to help manage stress and anxiety in dogs and cats. It consists of a specially blended feed to help promote relaxed behaviour in dogs and cats experiencing behavioural problems as a result of their surroundings or environment. It is fast-acting.Piper methysticum – a plant extract that has been used and proven for its natural calming properties over centuries.

For therapeutic use in dogs, DAP is made airborne. This is achieved by using short range plug-in diffusers, sprays or heat activated collars. Once airborne, DAP reaches the vomeronasal organ of the dog which is located in close proximity to the oral cavity and the nasal passage. The role of the vomeronasal is to respond to chemical messengers i.e. pheromones and initiate the appropriate response. Each pheromone produces a single, specific response and can only achieve this response in conspecifics. DAP invokes a calm and reassured mood. GABA is a major inhibitory neurotransmitter, with around 50% of inhibitory synapses being GABA mediated; these inhibitory synapses are prevalent at all levels of the CNS. In response to a stressor, the overall activity of GABA is decreased which results in a decrease in brain inhibition and thus reduces the likelihood of the brain achieving a calm state. Please note that parcels weighing over 2kg may be sent via courier due to Royal Mail weight restrictions. Next year, why not start early with a programme of desensitisation, to prevent the need for calming or sedative products? Ask to see one of our Behaviour trained vets or nurses for further information. Pereira et al. 2010. Effect of dietary intake of L-Tryptophan supplementation on working dogs demonstrating stress related behaviours. BSAVA congress 2010 Scientific Proceedings.

Treating anxiety and phobias with pharmaceuticals can be achieved with a variety of drugs, each with different pharmacodynamics. Anxiolytic and Amnesic Drugs L-tryptophan is a precursor of serotonin, an important hormone and neurotransmitter involved in regulating mood, behaviour and cognition. L-tryptophan has also been shown to decrease aggression in dogs (De Napoli et al, 2000), as well as decrease stereotypies and stress responses (Pereira et al, 2010). Bell C, Abrams J, Nutt D, 2001. Tryptophan depletion and its implications for psychiatry. Br J Psyschiatry. 2001 May; 178:399- 405 Calmex Canine Anxiety and Stress Relief Tabletsis a product that utilises a combination of two amino acids, a plant extract and numerous B vitamins to help calm anxious or stressed dogs.