Sublingual Vitamin B12 | Powder B12 Supplement | Highly Absorbable | 50g Powder | G&G Vitamins

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Henjum S, Manger M, Hampel D, Brantsaeter AL, Shahab-Ferdows S, Bastani NE, et al. Vitamin B12 concentrations in milk from Norwegian women during the six first months of lactation. Eur J Clin Nutr 2020;74:749-56. [ PubMed abstract] Most observational studies have found correlations between low serum vitamin B12 concentrations alone or in combination with high folate concentrations and poor cognitive function [ 82-87]. For example, an analysis of cross-sectional 2011–2014 NHANES data on 2,420 adults age 60 years or older found that low vitamin B12 (MMA greater than 0.27 micromol/L or serum vitamin B12 less than 203 pg/mL [150 pmol/L]) combined with high folic acid—unmetabolized serum folic acid greater than 0.44 mcg/L (1 nmol/L) or serum total folate higher than 32.7 mcg/L (74.1 nmol/L)—was associated with an almost two to three times higher risk of cognitive impairment [ 82].

Kennedy DO. B vitamins and the brain: mechanisms, dose and efficacy—a review. Nutrients. 2016;8(2):68. doi: 10.3390/nu8020068 Bailey RL, Jun S, Murphy L, Green R, Gahche JJ, Dwyer JT, et al. High folic acid or folate combined with low vitamin B-12 status: Potential but inconsistent association with cognitive function in a nationally representative cross-sectional sample of US older adults participating in the NHANES. Am J Clin Nutr 2020;112:1547-57. [ PubMed abstract] Other ingredients: soybean oil, gelatin, glycerin, yellow beeswax, water, rapeseed lecithin, colors added (including carmine)Vitamin B12 supplements come in different forms: pills, gummies, meltables, sprays, and liquids. B12’s bioavailability (absorption) from supplements has actually been shown to be higher than from food sources. One of the great things about a liquid supplement like this one is you have a lot of flexibility with the dosage. One serving (16 drops) provides 1,000 mcg, but you can easily consume more or less drops depending on your needs. So, this can serve as a low-dose, moderate-dose, or high-dose supplement. Li S, Guo Y, Men J, Fu H, Xu T. The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis. BMC Geriatr. 2021;21:367. doi: 10.1186/s12877-021-02253-3 Approximately 24% of men and 29% of women reported using a dietary supplement containing vitamin B12 in NHANES 2017–2018 [ 31]. The proportion in children ranged from 30% of those age 2–5 years to 10% of adolescents age 12–19. Mean vitamin B12 intakes among supplement users from both foods and supplements were 290.3 mcg for men age 20 and older, 402.5 mcg for women, and from 26.6 to 36.0 mcg for children. Vitamin B12 Deficiency Olaso-Gonzalez G, Inzitari M, Bellelli G, Morandi A, Barcons N, Viña J. Impact of supplementation with vitamins B6 , B12 , and/or folic acid on the reduction of homocysteine levels in patients with mild cognitive impairment: A systematic review. IUBMB Life. 2022;74(1):74-84. DOI: 10.1002/iub.2507

Estimated Average Requirement (EAR): Average daily level of intake estimated to meet the requirements of 50% of healthy individuals; usually used to assess the nutrient intakes of groups of people and to plan nutritionally adequate diets for them; can also be used to assess the nutrient intakes of individuals Most people should be able to get the amount of folate they need by eating a varied and balanced diet. If you're pregnant or could get pregnant Other ingredients: calcium phosphate, magnesium oxide, potassium chloride, calcium carbonate, cellulose gel, ascorbic acid, ferrous fumarate, modified food starch, d-alpha tocopheryl acetate, niacinamide, zinc oxide, d-calcium pantothenate, hypromellose, croscarmellose sodium, manganese sulfate, magnesium stearate, silicon dioxide, copper sulfate, pyridoxine hydrochloride, gelatin, thiamin mononitrate, riboflavin, retinyl acetate, polyethylene glycol, beta carotene, folic acid, boric acid, lutein, chromium picolinate, lycopene, potassium iodide, sodium selenate, sodium molybdate, biotin, phytonadione, sodium metavanadate, vitamin D3 Most multivitamins contain B12 at a lower dose than B12 supplements alone, which isn’t necessarily a bad thing. Especially since this multivitamin isn’t vegan-friendly anyway (it contains gelatin), most people taking this multi can meet their B12 needs from a combination of food sources of B12 and the supplement. There's not enough evidence to show what the effects may be of taking high doses of vitamin B12 supplements each day. What does the Department of Health and Social Care advise?Because these softgels contain gelatin, which is derived from cows or pigs, they’re not suitable for a vegan diet. Mikkelsen K, Stojanovska L, Apostolopoulos V. The Effects of Vitamin B in Depression. Curr Med Chem. 2016;23(38):4317-4337. [ PubMed abstract] Kornerup LS, Hvas CL, Abild CB, Richelsen B, Nexo E. Early changes in vitamin B12 uptake and biomarker status following Roux-en-Y gastric bypass and sleeve gastrectomy. Clin Nutr 2019;38:906-11. [ PubMed abstract] McCleery J, Abraham RP, Denton DA, Rutjes AW, Chong LY, Al-Assaf AS, et al. Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment. Cochrane Database Syst Rev 2018;11:CD011905. [ PubMed abstract] Djuric D, Jakovljevic V, Zivkovic V, Srejovic I. Homocysteine and homocysteine-related compounds: An overview of the roles in the pathology of the cardiovascular and nervous systems. Can J Physiol Pharmacol 2018;96:991-1003. [ PubMed abstract]

Han S, Wu L, Wang W, Li N, Wu X. Trends in dietary nutrients by demographic characteristics and BMI among US adults, 2003-2016. Nutrients 2019;11:2617. [ PubMed abstract] Gomollón F, Gargallo CJ, Muñoz JF, Vicente R, Lue A, Mir A, et al. Oral cyanocobalamin is effective in the treatment of vitamin B12 deficiency in Crohn's disease. Nutrients 2017;9:308. [ PubMed abstract] It is essential to carefully read the ingredient list and nutrition facts panel of a supplement to know which ingredients and how much of each ingredient is included, relative to the recommended daily value of that ingredient. Please bring the supplement label to a healthcare provider to review the different ingredients contained in the suppleme Dangour AD, Allen E, Clarke R, Elbourne D, Fletcher AE, Letley L, et al. Effects of vitamin B-12 supplementation on neurologic and cognitive function in older people: A randomized controlled trial. Am J Clin Nutr 2015;102:639-47. [ PubMed abstract]Slot WB, Merkus FW, Van Deventer SJ, Tytgat GN. Normalization of plasma vitamin B12 concentration by intranasal hydroxocobalamin in vitamin B12-deficient patients. Gastroenterology 1997;113:430-3. [ PubMed abstract]

There's not enough evidence to know what the effects might be of taking high daily doses of nicotinamide supplements. What does the Department of Health and Social Care advise? There's not enough evidence to know what the effects might be of taking high daily doses of pantothenic acid supplements. What does the Department of Health and Social Care advise? Exclusively breastfed infants of women who consume no animal products might have very limited reserves of vitamin B12 and can develop vitamin B12 deficiency, sometimes very early in life [ 56]. The infant’s deficiency can be severe, especially if the mother’s deficiency is severe or caused by pernicious anemia; sometimes, the mother’s own deficiency is clinically mild and not recognized. Undetected and untreated vitamin B12 deficiency in infants can result in neurological damage, failure to thrive, developmental delays, and anemia [ 2, 56, 57]. The reasons include the small amounts of vitamin B12 in the breast milk of vegan mothers as well as the limited amounts of vitamin B12 crossing the placenta in these women during fetal development. Vitamin B12 and Health The bacteria that live naturally in your bowel are also able to make vitamin B6. What happens if I take too much vitamin B6?

Liu Y, Wang X, Sun X, Lu S, Liu S. Vitamin intake and pancreatic cancer risk reduction: A meta-analysis of observational studies. Medicine (Baltimore) 2018;97:e0114. [ PubMed abstract] However, a few observational studies have found no such association [ 88, 89]. In addition, according to a systematic review of 35 prospective cohort studies in 14,325 participants age 47 to 101 years followed for an average of 5.4 years, the evidence does not support a role for low vitamin B12 in the development of cognitive impairment or dementia [ 90]. Langan RC, Goodbred AJ. Vitamin B12 deficiency: Recognition and management. Am Fam Physician 2017;96:384-9. [ PubMed abstract] Laird E, O'Halloran AM, Molloy AM, Healy M, Hernandez B, O'Connor D, Kenny RA, Briggs R. Low vitamin B12 but not folate is associated with incident depressive symptoms in community-dwelling older adults: a 4 year longitudinal study. Br J Nutr. 2021 Dec 13:1-22. [ PubMed abstract] B12 is also important for lowering the amount of Homocysteine found in your blood - this is a particularly harmful amino acid that’s been linked to an increased risk in things like heart disease, dementia, and Alzheimer’s disease. As such, Vitamin B12 doesn’t just take care of your body but also your brain."