Lemsip Max Cold and Flu Blackcurrant Sachets, With Paracetamol, Pack Of 10 (Packaging May Vary)

Product Information

Caffeine: Caffeine is absorbed readily from oral, rectal or parenteral administration, but absorption from the gastrointestinal tract may be erratic. There is little evidence of accumulation in any particular tissue. Caffeine passes readily into the central nervous system and into saliva. Concentrations have also been detected in breast milk. It is metabolised almost completely and is excreted in the urine as 1-methyluric acid, 1-methylxanthine and other metabolites, with only about 1% unchanged. Healthcare (UK) Ltd, Hull, HU8 7DS. Information about this product, including adverse reactions, precautions, contra-indications, Sympathomimetic amines: concomitant use of phenylephrine with other sympathomimetic amines can increase the risk of cardiovascular side effects.. Additional symptoms may include, hypertension, and possibly reflex bradycardia. In severe cases confusion, seizures and arrhythmias may occur. However the amount required to produce serious phenylephrine toxicity would be greater than that required to cause paracetamol-related liver toxicity. Treatment with activated charcoal should be considered if the overdose has been taken within 1 hour. Plasma paracetamol concentration should be measured at 4 hours or later after ingestion (earlier concentrations are unreliable). Treatment with N-acetylcysteine may be used up to 24 hours after ingestion of paracetamol, however, the maximum protective effect is obtained up to 8 hours post-ingestion. The effectiveness of the antidote declines sharply after this time. If required the patient should be given intravenous N-acetylcysteine, in line with the established dosage schedule. If vomiting is not a problem, oral methionine may be a suitable alternative for remote areas, outside hospital. Management of patients who present with serious hepatic dysfunction beyond 24 hours from ingestion should be discussed with the NPIS or a liver unit.

LEMSIP MAX COLD & FLU CAPSULES: Each capsule contains Paracetamol 500 mg, Caffeine 25 mg Phenylephrine hydrochloride 6.1 mg The systemic availability is subject to first-pass metabolism and varies with dose between 70% and 90%. The drug is rapidly and widely distributed throughout the body and is eliminated from plasma with a T½ of approximately 2 hours. The major metabolites are glucuronide and sulphate conjugates (>80%) which are excreted in urine. Immediate medical advice should be sought in the event of an overdose, even if the patient feels well because of the risk of delayed serious liver damage Taken during pregnancy it appears that the half-life of caffeine is prolonged. This is a possible contributing factor in hyperemesis gravidarum.The safety of this medicine during pregnancy and lactation has not been established but in view of a possible association of foetal abnormalities with first trimester exposure to phenylephrine, the use of the product during pregnancy should be avoided. In addition, because phenylephrine may reduce placental perfusion, the product should not be used in patients with a history of pre-eclampsia. reactions, precautions, contra-indications, and method of use can be found at: http://www.medicines.org.uk/emc/medicine/23352 for All-in-One relief of aches and pains, sore throat, headache, nasal congestion and lowering of temperature Legal Category: GSL.

Hull, HU8 7DS. Information about this product, including adverse reactions, precautions, contra-indications, and method of use can be Paracetamol: Paracetamol is absorbed rapidly and completely mainly from the small intestine producing peak plasma levels after 15-20 minutes following oral dosing.LEMSIP MAX DAY & NIGHT COLD & FLU RELIEF CAPSULES: Each day capsule contains Paracetamol 500 mg, Caffeine 25 mg, Phenylephrine Directions How to take: For oral use. Pour one sachet of powder into a mug and fill with hot, but not boiling, water. Stir until dissolved. If preferred, sweeten to taste with sugar, honey or your usual sweetener. How much to take: Adults, the elderly and children aged 16 years and over: 1 sachet every 4-6 hours. Do not take more than 4 sachets in 24 hours. Do not give to children under 16 years of age. Do not take more medicine than the label tells you to. If you do not get better, talk to your doctor. Do not take if: you are allergic to any ingredient, you have heart disease, high blood pressure, overactive thyroid, an enlarged prostate, or if you are taking or have taken MAOI's (antidepressants) within 14 days or other sympathomimetic, decongestants. Tricyclic antidepressants: Tricyclic antidepressants (e.g. amitriptyline) may increase the risk of cardiovascular side effects with phenylephrine (see section 4.3).

Paracetamol: Paracetamol is absorbed rapidly and completely mainly from the small intestine, producing peak plasma levels after 15-20 minutes following oral dosing. The systemic availability is subject to first-pass metabolism and varies with dose between 70% and 90%. The drug is rapidly and widely distributed throughout the body and is eliminated from plasma with a T ½ of approximately 2 hours. The major metabolites are glucuronide and sulphate conjugates (>80%) which are excreted in urine. Immediate medical advice should be sought in the event of an overdose, even if the patient feels well because of the risk of delayed serious liver damage (see section 4.9). Symptoms of paracetamol overdosage in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12-48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported.It comes in a few different variations and has plenty of tablet alternatives if you do not want to have your medicine in a sachet form. Symptoms of paracetamol overdose in the first 24 hours are pallor, nausea, vomiting, anorexia and abdominal pain. Liver damage may become apparent 12 to 48 hours after ingestion. Abnormalities of glucose metabolism and metabolic acidosis may occur. In severe poisoning, hepatic failure may progress to encephalopathy, haemorrhage, hypoglycaemia, cerebral oedema and death. Acute renal failure with acute tubular necrosis, strongly suggested by loin pain, haematuria and proteinuria, may develop even in the absence of severe liver damage. Cardiac arrhythmias and pancreatitis have been reported. Due to its aspartame content this medicinal product should not be given to patients with phenylketonuria.

Sympathomimetic agents: Concomitant use of phenylephrine with other sympathomimetic amines can increase the risk of hypertension and other cardiovascular side effects (see section 4.3). Liver damage is possible in adults who have taken 10 g or more of paracetamol. Ingestion of 5 g of more of paracetamol may lead to liver damage if the patient has risk factors (see below). a) Is on long-term treatment with carbamazepine, phenobarbitone, phenytoin, primadone, rifampicin, St. John's Wort or other drugs that induce liver enzymes, orThis medicinal product contains 128.71 mg sodium per dose, equivalent to 6.4 % of the WHO recommended maximum daily intake for sodium. The product should not be used during pregnancy unless recommended by a healthcare professional (see section 4.6).