B Braun D5613 Wound Irrigation Solution, 350ml

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Goswami K, Austin MS. Intraoperative povidone-iodine irrigation for infection prevention. Arthroplasty Today. 2019; 5:30–308. b. [ PMC free article] [ PubMed] [ Google Scholar] Surgical debridement → 3L CHG b irrigation → 3L NS irrigation → re-drape → 1L NS irrigation → modular component exchange Kim JH, Rimmer J, Mrad N, Ahmadzada S, Harvey RJ. Betadine has a ciliotoxic effect on ciliated human respiratory cells. J Laryngol Otol. 2015; 129:S45–50. [ PubMed] [ Google Scholar]

Betaine acts as surfactant to aid with debridement. Polyhexanide is a preservative. The combination of the two products provides a lower surface tension than water and improves biofilm removal in wounds.

The solution for acute, chronic and burn wounds

Haddad FS, Sukeik M, Alazzawi S. Is single-stage revision according to a strict protocol effective in treatment of chronic knee arthroplasty infections? Clin Orthop Relat Res. 2015; 473:8–14. [ PMC free article] [ PubMed] [ Google Scholar] Created by white blood cells during the oxidative burst to kill pathogens. HOCl is additionally produced by neutrophils, macrophages, monocytes, andmyeloperoxidase-catalyzed peroxidation ofchloride ions. The residual chloride ions oxidize the surrounding bacterial cells in a similar mechanism to sodium hypochlorite, except in a slightly more acidic pH5.5.

Staphylococcus epidermidis, Haemophilus influenzae, Pseudomonas aeruginosa, and E.coli) on orthopaedic materials such as stainless-steel screws, titanium discs, Physically deconstructs the protective EPS matrix, making pathogens more susceptible to traditional antibiotics and the body's normal defense mechanism. Wound lavage assists with mechanical removal of organisms. Debriding aids in the removal of biofilm, debris and slough from the wound bed. Combined with the use of a surfactant based wound cleansing solution, it will cleanse the wound sufficiently to remove and disrupt the biofilm. Cichos KH, Andrews RM, Wolschendorf F, Narmore W, Mabry SE, Ghanem ES. Efficacy of Intraoperative Antiseptic Techniques in the Prevention of Periprosthetic Joint Infection: Atkin et al, (2020) Wound bed preparation: a case series using polyhexanide and betaine solution and gel—a UK perspectiveProntosan Irrigation Solution. B.Braun; [last access: 1May2021]. available at: https://www.bbraunusa.com/en/products/b4/prontosan-irrigationsolution.html . [ Google Scholar] Surgical debridement → 3–6L NS pulse lavage → modular component exchange versus head and liner replacement after 10–15min 97% ethanol soak → PI 10% soak 5–10min → 3L NS irrigation Newton H, Edwards J, Mitchell L, Percival SL. Role of slough and biofilm in delaying healing in chronic wounds: The management of biofilms with maintenance desloughing and antimicrobial therapy is fast becoming the accepted treatment strategy for chronic wounds. British journal of nursing 2017; 20(S20a): S4-S11. Andriessen AE, Eberlein T. Assessment of a wound cleansing solution in the treatment of problem wounds. Wounds: A Compendium of Clinical Research & Practice 2008; 20(6): 171-5. The use of multiple additives with normal saline solution irrigation to improve bacterial bioburden eradication is

Ruder JA, Springer BD. Treatment of Periprosthetic Joint Infection Using Antimicrobials: Dilute Povidone–Iodine Lavage. J Bone Joint Infect. 2017; 2:10–14. doi: 10.7150/jbji.16448. [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar] Tsang STJ, Gwynne PJ, Gallagher MP, Simpson AHRW. The biofilm eradication activity of acetic acid in the management of periprosthetic joint infection. Bone Joint Res. 2018; 7:517–523. doi: 10.1302/2046-3758.78.BJR-2018-0045.R1. b. [ PMC free article] [ PubMed] [ CrossRef] [ Google Scholar]International Wound Infection Institute. Wound infection in clinical practice. Wounds International, 2016 TKA: 96.8% (487/503) at 3 months 93.4% (298/319) at 12 months THA: 96.3% (367/381) at 3 months 94.8% (219/231) at 12 months